The main hurdle in bone tissue repair is maintaining appropriate vascularization for regeneration of large-scaled defects. We fabricate engineered constructs, capable of soft and hard tissue repair. These pre-vascularized composite grafts are fabricated from FDA approved and biocompatable biomaterials, which undergo an induction phase by differential seeding with diverse cellular components. Our bone tissue engineering (BTE) models are treated from a clinical perspective, utilizing in vivo imaging and CAD-CAM interfaces to produce defect-specific grafts. These engineered constructs are implanted in live animal models to assess their ability to regenerate complex anatomical structures.
This study is supported by the Israel science foundation.